Research chemicals, often described "novel psychoactive drugs," present a considerable challenge due to their changing nature. These items are typically created for laboratory exploration, but are sometimes encountered in the recreational drug trade. The absence of extensive data on their long-term effects means users face considerable medical risk

A worrying combination is surfacing among individuals: the concurrent consumption of legal lean syrup – often containing dextromethorphan – and kratom, a Southeast Asian plant. This hazardous pairing presents grave physical risks. Both substances independently carry considerable risk, but their combined effect can intensify unfavorable effects